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First, SELECT was designed as a CV outcomes trial and not a weight-loss trial, and weight loss was only a supportive secondary endpoint in the trial design

Before KOHJINs groundbreaking work, science knew only this about GSH, and suspected there was no recourse from that inevitable decline

Clinical trial data and post-marketing surveillance have documented gastrointestinal complaints in a substantial proportion of patients, with nausea being the most frequent (reported in 1540% of patients depending on the specific agent and dose), followed by vomiting, diarrhoea, constipation, and dyspepsia